Welcome to TopoGEN
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TopoGEN provides innovative reagents and kits for topoisomerase research and mechanism-based drug development in cancer. Kits are available to assay for topoisomerases (I, II, IV and gyrase) and Tdp1, to measure topo/DNA interactions in vivo and to identify new topoisomerase drugs. We also offer a complete line of DNA substrates topo inhibitors, antibodies, and kit replenishment reagents. Our staff can offer hands on assistance with your topo research. We offer training and technology transfer at your site...please enquire.

Contract Screening for topo poisons  now available. 

RECENTLY ADDED PRODUCTS

 Bacterial E. Coli DNA Gyrase:  We can provide extremely high activity DNA gyrase to meet your screening needs.  Our gyrase is of high purity and very stable. We offer substantial discounts for large orders.  Please ask for details.

 Recombinant Human Topo I Enzyme Overexpressed in baculovirus 2005H-RC1.  We can provide large quantities for physical studies.

 Mutant Human Topo I Enzyme expressed in Baculovirus. We have mutated the active site tyrosine and can make tractable quanties of this important mutant. Go to 2005H-Y723F

 Topo I Western Blot Marker. We have a marker for topo I on Westerns. Our customers love this one since endogenous topo I often is hard to identify on blots.  With cat# 2011-4 we take out the guess work. 

 A suite of products related to Human Tyrosyl DNA Phosphodiesterase (Tdp1).  Including purified Tdp1 which has excellent catalytic activity (will remove a terminal 3’ phosphotyrosyl group from a specifically designed oligo target site). Anti-Tdp1 antibody and Tdp1 assay kits are also available.

New rabbit polyclonal topo IIb antibody.  We now offer a great polyclonal AB to the 180 kDA form of topo II. This reagent works great for IHC, IF, IP and Westerns. We are offering this in a trial size as well.  See Catalog number 2010-3 for more information. We also offer a rabbit anti-topo IIIb antibody that works great for Westerns

Want to quantify your topo gel assay data or topo cleavage data?
GO HERE for more information.

We offer custom screening on a contract basis. Let us test your compounds for topo targeting activity.

Print our catalog in acrobat format (PDF).

PRICE LIST

MAILING ADDRESS
TopoGEN, Inc.
108 Aces Alley
Port Orange, FL, USA 32128
info@topogen.com
Tel  614-451-5810
Fax  614-559-3932

 Link to Product Order Page

Technical Questions?
Email support@topogen.com

Copyright TopoGEN, Inc., 2007
All rights reserved
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Updated December 26, 2006

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