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The Topoisomerase IV Drug Screeing Kit is designed for researchers who wish to measure the realease of topoisomerase from covalent complexes that form as a result of drug treatment. It is highly specific and can be quantified.
For those looking for background about the human topoisomerase II alpha protein and its role as a decatenating check-point during mitosis, an informative article originally published in Oncogene is available here. Nuclear extrac...
This Merck study was published in Cell and showcases the use of our E. coli DNA Gyrase and Topo IV assay protocols in identifying a new class of Topo II inhibitor. The following type II topoisomerase...
TopoGEN is a research diagnostic company that provides innovative products for researchers working with topoisomerases and engaged in mechanism based drug discovery. Kits are available to identify topoisomerase active drugs for use in cancer chemotherapy and antibacterial applications. The company also provides kits for assaying both prokaryotic and eukaryotic topoisomerases (type I, II, IV, gyrase), both in vitro and in vivo.
We also offer a complete line of DNA substrates and DNA cleavage targets, topo inhibitors, antibodies, and kit replenishment reagents. The company was founded by researchers working