Topoisomerase assay kits, drug kits, antibody kits

Detailed information about TopoGEN kits can be found at the following links:

Tdp1 Assay Kit: This is a new kit from TopoGEN, Inc. It is designed for researchers who wish to measure release of topo from covalent complexes that form as a result of drug treatment. It is highly specific and can be quantified. NEW KIT ON THE BLOCK!

Topoisomerase II Assay Kit: This kit is designed for researchers who wish to measure topo II activity in a crude extract. It is highly specific and can be quantified.

Topoisomerase I Assay Kit: A specific assay for topo I in a crude mixture of heterologous proteins. It is generally easy to interpret an assay that quantifies topo I activity.

DNA Gyrase Assay Kit: This kit will allow one to quantify gyrase activity in a crude mix of other proteins (other topo enzymes for example). It is ideal for characterizing inhibitors as well.

Topoisomerase II Drug Screening Kit: This kit will help you interpret how a novel drug affects topo II action.

Topoisomerase I Drug Screening Kit: The drug kit allows the researcher to model drug action with novel topo I active agents. For example, is it a poison or an inhibitor?

SDS-K+ Precipitation Kit: Designed for researchers who wish to monitor topo I or II covalent binding to a DNA target in vitro AND in vivo.

In Vivo Link Kit (Topoisomerase I or II): Very powerful method to deduce whether a given drug actually affects its predicted topo target in a given cancer cell in vivo. One can quantify the activity of topo in vivo with this kit.

DNA Unwinding Kit: Some drugs intercalate and unwind the DNA helix. This kit will reveal such activities.

Topoisomerase II Immonofluorescence Kit: Cytologically track topo II in cells with this kit. Controls are included along with detailed documentation on use of TopoGEN antibodies.

Topoisomerase II Immunoprecipitation Kit: Those interested in protein/protein interactions will find this kit useful.

DNA Gyrase + Relaxed DNA Assay Kit: TopoGEN sells E. coli gyrase along with the relaxed subtrate. The enzyme is very active and can be purchased in large quantities for screening studies.

We offer custom screening on a contract basis. Let us test your compounds for topo targeting activity.