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Topoisomerase I In Vivo Link Kit

The Topoisomerase I in vivo Link Kit offers a very powerful method to deduce whether a given drug actually affects its predicted topo target in a given cancer cell in vivo. One can quantify the activity of topoisomerase enzyme in vivo with this kit.

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TopoGEN Blog

Study Reveals Novel Approach to Reducing Toxic Effects of Amonafide

This study which originally was published in Bioorganic and Medicinal Chemistry in November 2013, describes a novel approach to reducing the toxic side effects of amonafide, a drug used in the treatment of cancer which is consider...

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TopoGEN News

Latest Google Scholar Results

Complete listing of the latest Google Scholar results that reference the use of TopoGEN Products....

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Why TopoGEN?

TopoGEN is a research diagnostic company that provides innovative products for researchers working with topoisomerases and engaged in mechanism based drug discovery. Kits are available to identify topoisomerase active drugs for use in cancer chemotherapy and antibacterial applications. The company also provides kits for assaying both prokaryotic and eukaryotic topoisomerases (type I, II, IV, gyrase), both in vitro and in vivo.

We also offer a complete line of DNA substrates and DNA cleavage targets, topo inhibitors, antibodies, and kit replenishment reagents. The company was founded by researchers working

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