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Custom Screening Services and Contract R&D
TopoGEN offers turn-key, custom screening services to screen for new Topo Drugs that target Human Topo I, Topo II, Topo IV and DNA Gyrase. As an Experienced CRO, the advantages are numerous! Our group has >30 years experience as a Contract Research Organization. We guarantee clear, cosmetic data, unambiguous interpretations, and that you will receive publication quality results. Since we are seasoned veterans in the arena of in vitro testing, we can help you develop a tractable strategy for analysis of drug mechanisms in the context of the tumor cell. We can evaluate potential genotoxicity independently from topo effects without extra charge.
All our topo enzymes are homogeneously pure. We do not screen using extracts. Controls with specific drugs (e.g. etoposide vs. Top2a) guarantee specificity in all assays and validate even negative results with unknowns.
Additionally, we produce quality topoisomerases & related assay and drug screening kits as technology transfer platforms from our lab to yours. When you become our customer, we become your partner in research. We review your data and offer valuable input. Feel free to contact us for further information about how we can assist your topoisomerase research endeavors.
HUMAN TOPO SCREENING IN VITRO
We can help! Let us design a tractable screen to validate your novel small molecule or natural product. We do this routinely for researchers who want high quality, unambiguous results in a short time frame. Go HERE to fill out a screening request and we can generate a quote. Projects run (typically) for a few business days to a few weeks depending on number of compounds being screened. We cover all the bases: we can test multiple enzymes for a comprehensive result and, we’ll determine the mechanism of action of your novel drug.
BACTERIAL GYRASE & TOPO IV SCREENING
We can help! Let us design a tractable screen to validate and test for antibiotic activity. Everyone knows that DNA Gyrase is an excellent target protein for new antibiotics. You may have the next big bug buster! We do this routinely for researchers who want high quality, unambiguous results in a short time frame. Go HERE to fill out a screening request and we can generate a quote. Projects run (typically) for a few business days to a few weeks depending on number of compounds being screened. We cover all the bases: we can test multiple enzymes for a comprehensive result and, we’ll determine the mechanism of action of your new antibiotic.
CELL CONTEXT TOPOISOMERASE SCREENING (ICE ASSAYS)
If you want it done quickly and clearly, let us help. We have a number of different cell lines (please enquire) or you can send us your cells; either way we’re here to help. Note that our ICE Assay Kits are based on specific antibodies, so you know what topo isoform you are targeting!