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Topoisomerase I In Vivo Link Kit

The Topoisomerase I in vivo Link Kit offers a very powerful method to deduce whether a given drug actually affects its predicted topo target in a given cancer cell in vivo. One can quantify the activity of topoisomerase enzyme in vivo with this kit.

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TopoGEN Blog

Topo I and Cobalt Complex

Revealing new paper on metallo-inhibitors. Article Source: Science Direct Synthesis and structure elucidation of a cobalt(II) complex as topoisomerase I inhibitor: In vitro DNA binding, nuclease and RBC hemolysis Abstract...

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TopoGEN News

Topoisomerase II Targeting and Resveratrol

In this paper the authors use a decatenation assay to identify some new topoisomerase II inhibitors from resveratrol. kDNA substrate was provided by TopoGEN. Article Source: Journal of Agricultural and Food Chemistry Topo...

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Why TopoGEN?

TopoGEN is a research diagnostic company that provides innovative products for researchers working with topoisomerases and engaged in mechanism based drug discovery. Kits are available to identify topoisomerase active drugs for use in cancer chemotherapy and antibacterial applications. The company also provides kits for assaying both prokaryotic and eukaryotic topoisomerases (type I, II, IV, gyrase), both in vitro and in vivo.

We also offer a complete line of DNA substrates and DNA cleavage targets, topo inhibitors, antibodies, and kit replenishment reagents. The company was founded by researchers working

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