Topoisomerase levels determine chemotherapy response in vitro and in vivo Darren J. Burgess*, Jason Doles†, Lars Zender*, Wen Xue*, Beicong Ma*‡, W. Richard McCombie*, Gregory J. Hannon*‡, Scott W. Lowe*‡§, and Michael T. Hemann*† *Cold Spring Harbor Laboratory and ‡Howard Hughes Medical Institute, 1 Bungtown Road, Cold Spring Harbor, NY 11724; and †Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139 Communicated by Michael H. Wigler, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, April 14, 2008 (received…

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A non-canonical function of topoisomerase II  in disentangling dysfunctional telomeres Thomas Germe, Kyle Miller1 and  Julia Promisel Cooper Telomere Biology Laboratory, Cancer Research, London, UK The decatenation activity of topoisomerase II (Top2), which is widely conserved within the eukaryotic domain, is essential for chromosomal segregation in mitosis.  It is less clear, however, whether Top2 performs the same function uniformly across the whole genome, and whether all its functions rely on decatenation.  In the fission yeast, Schizosaccharomyces pombe, telomeres are bound…

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