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Month: May 2011

DNA Decatenation Study

DNA Decatenation Study

BRCA1 Participates in DNA Decatenation Zhenkun Lou, Katherine Minter-Dykhouse & Junjie Chen The tumor suppressor BRCA1 has an important function in the maintenance of genomic stability. Increasing evidence suggests that BRCA1 regulates cell cycle checkpoints and DNA repair after DNA damage. However, little is known about its normal function in the absence of DNA damage. Here we show that BRCA1 interacts and colocalizes with topoisomerase IIa in S phase cells. Similar to cells treated with the topoisomerase IIa inhibitor ICRF-193,…

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