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Month: October 2011

Topoisomerase I and DNA Relaxation

Topoisomerase I and DNA Relaxation

Par-4 Binds to Topoisomerase I and Attenuates Its DNA Relaxation Activity The authors of this paper have identified a tumor suppressor protein that regulates Topo I, and in so doing provide a nice review of the mechanistic nature of DNA and cancer cell metabolism.  Human Topo I and polyclonal antibodies were provided by TopoGEN. Article Source: Cancer Research Website

Genomic Instability and Topo II

Genomic Instability and Topo II

For those looking for background about the  human topoisomerase II alpha protein and its role as a decatenating check-point during mitosis, an informative article originally published in Oncogene is available here.  Nuclear extracts were assayed for decatenation using the Human Topoisomerase II Assay Kit.  Human Topoisomerase II is available from TopoGEN. Article Source: NIH Public Access Website