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Month: April 2012

New: Updated Kit Protocols…Now Available for Download!

New: Updated Kit Protocols…Now Available for Download!

We have updated the protocols of our most popular Topoisomerase Assay and Drug Screening Kits – better graphics, an FAQ section, and visual layouts that are easier on the eye.  Whats more is that these protocols are now available for download here!  Check back as we upload more protocols in the coming weeks.  The following new protocols are available on the Product Page for each kit under “Related Documents:” Human Topoisomerase II Assay Kit TG1001 Topoisomerase I Assay Kit TG1015…

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Topo I Enzyme Provided for Autoimmunity Study

Topo I Enzyme Provided for Autoimmunity Study

Immunization with DNA topoisomerase I and Freund’s complete adjuvant induces skin and lung fibrosis and autoimmunity via interleukin-6 signaling. Abstract OBJECTIVE: The presence of anti-DNA topoisomerase I (anti-topo I) antibody correlates positively with disease severity in patients with systemic sclerosis (SSc). However, the role of induction of anti-topo I antibody production and its potential contribution to the pathogenesis of SSc remain unclear. The aim of this study was to examine the role of anti-topo I antibody in the pathogenesis of…

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