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Month: January 2013

Mutations and Drug Resistance: Topo I and Irinotecan

Mutations and Drug Resistance: Topo I and Irinotecan

Low efficacy of a particular class of anti-cancer agents is discussed in this article. The authors hypothesize that Topoisomerase I mutations cause a resistance to Irinotecan, a commonly used drug for the treatment of colon cancer. Article Source: Molecular Cancer New Topoisomerase I mutations are associated with resistance to camptothecin Abstract Background: Topoisomerase I (TOP1) is a nuclear enzyme that catalyzes the relaxation of supercoiled DNA during DNA replication and transcription. TOP1 is the molecular target of camptothecin and related…

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Findings on the Dissasemblage of Particular Nuclear Subdomain in Tumor Cells

Findings on the Dissasemblage of Particular Nuclear Subdomain in Tumor Cells

The authors discuss the particulars of the perinucluear compartment in DNA and its effects on the DNA integrity of a tumor rich environment. Human Topo I Antibody provided by TopoGEN. Article Source: The Journal of Biological Chemistry The Perinucleolar Compartment Is Directly Associated with DNA Abstract The perinucleolar compartment (PNC) is a nuclear subdomain that is unique to tumor cells, and the percentage of cells in a population containing PNCs (PNC prevalence) indicates the level of malignancy of that population….

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