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Month: May 2014

Study Reveals Novel Approach to Reducing Toxic Effects of Amonafide

Study Reveals Novel Approach to Reducing Toxic Effects of Amonafide

This study which originally was published in Bioorganic and Medicinal Chemistry in November 2013, describes a novel approach to reducing the toxic side effects of amonafide, a drug used in the treatment of cancer which is considered a topoisomerase II poison. Article Source: Science Direct Synthesis and study of antiproliferative, antitopoisomerase II, DNA-intercalating and DNA-damaging activities of arylnaphthalimides Abstract A series of arylnaphthalimides were designed and synthesized to overcome the dose-limiting cytotoxicity of N-acetylated metabolites arising from amonafide, the prototypical…

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