Study Reveals Novel Approach to Reducing Toxic Effects of Amonafide
This study which originally was published in Bioorganic and Medicinal Chemistry in November 2013, describes a novel approach to reducing the toxic side effects of amonafide, a drug used in the treatment of cancer which is considered a topoisomerase II poison. Article Source: Science Direct Synthesis and study of antiproliferative, antitopoisomerase II, DNA-intercalating and DNA-damaging activities of arylnaphthalimides Abstract A series of arylnaphthalimides were designed and synthesized to overcome the dose-limiting cytotoxicity of N-acetylated metabolites arising from amonafide, the prototypical…