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Month: June 2016

Exciting New Findings on Top1 as Target for Mitigating the Proinflammatory Response

Exciting New Findings on Top1 as Target for Mitigating the Proinflammatory Response

See Rialdi et al., Science 352 aad7993 Summary Topoisomerase I (Top1) represents an exciting new target in regulating host defense against pathogenic insult. Specifically, the balance between pro- and anti-inflammatory outcomes depends critically on equilibrium levels of endogenous Top1. Pharmacological intervention of Top1 action in chromatin therefore represents a novel and exciting inroad in treating acute inflammation which can be lethal in some cases. Why is this exciting? The innate immune response is a pivotal and early onset protection mechanism…

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