About us

TopoGEN is a research diagnostics company that provides innovative products and services for researchers working with DNA Topoisomerases as well as DNA repair.  Scientists engaged in mechanism-based anticancer, anti-viral and antibacterial drug discovery will find our products particularly useful in R&D.  Our Drug Screening Kits are available to unambiguously identify topoisomerase targeting molecules for use in cancer chemotherapy and antibacterial applications. The company also sells  assay kits  that detect and quantify both prokaryotic (DNA Gyrase, Topoisomerase IV) and eukaryotic topoisomerases (Topoisomerase I, IIa, IIb, III).  We also offer a complete line of DNA substrates and DNA cleavage targets, topoisomerase inhibitors, topoisomerase antibodies, and kit replenishment reagents.  A related series of products on DNA repair are also a key part of our offering.  Topoisomerase drugs often induce genomic DNA damage, thereby killing the tumor cell.  When combined with agents that mitigate or inhibit DNA repair, the panoply of Topo Drugs and their tumor cell killing, may be significantly elevated.  For this reason, TopoGEN scientists have also developed highly specific cell lines that allow researchers to interrogate endogenous DNA repair pathways (Homologous Recombination Repair or HR and Non-Homologous End Joining or NHEJ) all within the context of the live cell. Drugs that target HR and NHEJ will likely synergize with existing and newly discovered Topo drugs.  This is a powerful combinatorial approach and we can help you with both novel topo drug discovery as well as finding agents that cripple HR and NHEJ.

The company was founded by researchers working specifically with Topoisomerases and DNA repair in cell contexts.  We can offer hands on assistance with your drug identification search at both levels and complement your basic, clinical, applied or translational R&D projects. TopoGEN has been providing important reagents for science since the 1990’s with repeat customers and a dedicated clientele.  All of our products include ongoing consulting and product support, including data analysis.  Buy from us with confidence.  We strongly support all of our products.  We are an effective on-stop shop for your R&D needs in tech transfer operations in drug discovery.  Finally, for those interested in an outsourcing relationship, we can provide a turn-key solution to your drug screening R&D enterprise.  Let’s face it, labor costs are high and rate limiting in most organizations.  Let the professionals at TopoGEN do the heavy lifting and convert a 6-month in-house operation to a 6 day contract, certified and guaranteed to be publication quality with clear and unambiguous data.  Eliminate costly learning curve issues with your staff.  We can help.  Please see our custom screening services for more information on drug screening, HR-NHEJ pathway screens and mechanistic Hit to Lead optimizations.

TopoGEN, Inc. was created by NIH funded investigators in Topoisomerases who understand the needs of other researchers in related areas, such as DNA repair.  Our team recognizes the unique details of topoisomerase drug discovery.

We manufacture and sell research quality reagents and understand the standards of evidence required for publications and patents. Our technical support staff is dedicated to providing you, the researcher, with the training and acumen you need to complete your research goals. Other ‘big box’ companies cannot do this–they get their enzymes from someone else and hand them over to you. They cannot provide the detailed expertise that we offer.

Our contract screening service offers you powerful, mechanism based custom screens developed and conducted entirely in house. Our cell based (in vivo) screens for detecting topoisomerase I and II poisons in the context of the cancer cell represents the new gold standard for identification of novel anti cancer agents.

Feel free to contact us for further information about how we can assist your topoisomerase research endeavors.