Cytotoxicity and topoisomerase I/II inhibition of glycosylated 2-phenyl-indoles, 2-phenyl-benzo[b]thiophenes and 2-phenyl-benzo[b]furans Wei Shia, Sandra L. Marcusa and Todd L. Lowary Alberta Ingenuity Centre for Carbohydrate Science and Department of Chemistry, The University of Alberta, Gunning-Lemieux Chemistry Centre, Edmonton, AB T6G 2G2 Canada Abstract A panel of glycosylated DNA binding agents (1–12) designed as functional anthracycline mimics was screened against three solid-tumor cell lines (MCF-7, HT 29 and HepG2/C3A) and three non-tumor cell lines by the MTS (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium) cell viability assay….
Substituent control of DNA binding modes in a series of chalcogenoxanthylium photosensitizers as determined by isothermal titration calorimetry and topoisomerase I DNA unwinding assay References and further reading may be available for this article. Ruel E. McKnighta, Corresponding Author Contact Information, E-mail The Corresponding Author, Bilgehan Onogula, Shivani R. Polasania, Michael K. Gannon IIb and Michael R. Dettyb, Corresponding Author Contact Information, E-mail The Corresponding Author Department of Chemistry, State University of New York at Geneseo, 1 College Circle, Geneseo,…
At the AACR 102nd Annual Meeting 2011, participants will present, discuss, and learn in a variety of settings: plenary lectures, symposia, minisymposia, workshops, poster sessions, and other formats. Please click the following link for Full Information on the AACR Annual Meeting in 2011
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