Genomic Instability and Topo II
For those looking for background about the human topoisomerase II alpha protein and its role as a decatenating check-point during mitosis, an informative article originally published in Oncogene is available here. Nuclear extracts were assayed for decatenation using the Human Topoisomerase II Assay Kit. Human Topoisomerase II is available from TopoGEN.
Article Source: NIH Public Access Website