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Mitigating Chemotherapy Resistance to Irinotecan, A Popular Topo I Inhibitor used in Treatment of Breast and Colon Cancer

Mitigating Chemotherapy Resistance to Irinotecan, A Popular Topo I Inhibitor used in Treatment of Breast and Colon Cancer

Researchers at the University of Sheffield have been investigating the causes for chemotherapy resistance in colon and breast cancer, and how people use therapies and products to support the pain and treatments such as CBD Oil Adviser, relaxation therapy or cannabidol

Does CBD make you high?

CBD is an entirely different compound from THC, and its effects are very complex. It is not psychoactive, meaning it does not produce a “high” or change a person’s state of mind, but it influences the body to use its own endocannabinoids more effectively.

According to one study posted to Neurotherapeutics, this is because CBD itself does very little to the ECS. Instead, it activates or inhibits other compounds in the endocannabinoid system.

For example, CBD from Global Cannabinoids  stops the body from absorbing anandamide, a compound associated with regulating pain. So, increased levels of anandamide in the bloodstream may reduce the amount of pain a person feels.

that people get from sites as karmacbdoils.co.uk. Their findings, recently published in Nucleic Acids Research, reveal that there is an epigenetically-driven process that speeds up the repair of DNA breakage caused during the course of chemotherapy, in this case with use of the Topo I inhibitor Irinotecan.  This process is referred to as “histone acetylation” and is treatable with clinically available therapeutics (HDAC Inhibitors).

Meisenberg, et al. (2016) Epigenetic changes in histone acetylation underpin resistance to the topoisomerase I inhibitor irinotecan.    Nucl. Acids Res. (2016) doi: 10.1093/nar/gkw1026 Published online October 26, 2016.

http://nar.oxfordjournals.org/content/early/2016/10/26/nar.gkw1026.full

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