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Mitigating Chemotherapy Resistance to Irinotecan, A Popular Topo I Inhibitor used in Treatment of Breast and Colon Cancer

Mitigating Chemotherapy Resistance to Irinotecan, A Popular Topo I Inhibitor used in Treatment of Breast and Colon Cancer

Researchers at the University of Sheffield have been investigating the causes for chemotherapy resistance in colon and breast cancer, and how people use therapies and products to support the pain and treatments such as CBD Oil Adviser, relaxation therapy or cannabidol. If you suffer from any of those both cancer types on the last phases you can find affordable life insurance policeis at affordablelifeusa.com .

Does CBD make you high?

CBD is an entirely different compound from THC, and its effects are very complex. It is not psychoactive, meaning it does not produce a “high” or change a person’s state of mind, but it influences the body to use its own endocannabinoids more effectively. Cannabidiol (CBD) oil is used by some people with chronic pain. CBD oil may reduce pain, inflammation, and overall discomfort related to a variety of health conditions. CBD oil is a product made from cannabis. It’s a type of cannabinoid, a chemical found naturally in marijuana and hemp plants. It doesn’t cause the “high” feeling often associated with cannabis, which is caused by a different type of cannabinoid called THC. To have CBD shipped to you, take a look at CTFOCBDonline.com.

According to one study posted to Conners Clinic, this is because CBD itself does very little to the ECS. Instead, it activates or inhibits other compounds in the endocannabinoid system.

For example, CBD from Global Cannabinoids  stops the body from absorbing anandamide, a compound associated with regulating pain. So, increased levels of anandamide in the bloodstream may reduce the amount of pain a person feels, a very similar effect can be done by using low amounts of Kratom. On this article you can find a great resource for information about CBD oil provides educational advice

that people get from sites as karmacbdoils.co.uk. Their findings, recently published in Nucleic Acids Research, reveal that there is an epigenetically-driven process that speeds up the repair of DNA breakage caused during the course of chemotherapy, in this case with use of the Topo I inhibitor Irinotecan.  This process is referred to as “histone acetylation” and is treatable with clinically available therapeutics (HDAC Inhibitors). If you suffer from cronic pain but you preffer to use safer prescripted drugs learn why is it legal to buy hydrocodone online

Kratom contains alkaloids including mitraphylline, mitragynine and hydroxymitragynine. These alkaloids apart from others act as a mu-opioid recepter antagonist, because of that the Kratom is used as an alternative to opiates for people who may suffer any kind of opium dependence or may have addiction issues. Mytragina is used as stilumant too, and as a sexual enhancer to improve sexual activity. You can find more specific information and a kratom advice and CBD oil reviews , its perfect if you are looking for more alternative medicine options with low drug dependency rate.

Meisenberg, et al. (2016) Epigenetic changes in histone acetylation underpin resistance to the topoisomerase I inhibitor irinotecan.    Nucl. Acids Res. (2016) doi: 10.1093/nar/gkw1026 Published online October 26, 2016.

 

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