TopoGEN has developed a kit to clearly demonstrate topo I and II poisoning in the context of the cell. Use of the In Vivo Link Kit™ provides the researcher unambiguous evidence of drug efficacy within tumor cells. Frequently, when a new drug or compound is identified as a topo targeting agent, the investigator needs to ask basic questions about its entry into the cell. For example, a positive in vitro hit may not translate into the context of a tumor cell. This is where our In Vivo Link Kit comes into play: the kit will demonstrate clearly whether a drug actually enters the nucleus and targets the topo enzyme in question. We developed this technology and it is widely used and accepted as a gold standard for in vivo targeting. If your drug is pure, you might even try testing as a low throughput screening assay. Please click one of the links below for further information.