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Topoisomerase I and DNA Relaxation

Par-4 Binds to Topoisomerase I and Attenuates Its DNA Relaxation Activity

The authors of this paper have identified a tumor suppressor protein that regulates Topo I, and in so doing provide a nice review of the mechanistic nature of DNA and cancer cell metabolism.  Human Topo I and polyclonal antibodies were provided by TopoGEN.

Article Source: Cancer Research Website

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