A very nice paper has been recently published in the free access journal PLoS One. These investigators are starting to ask important structural questions about how Topotecan, a clinically useful topoisomerase I poison, interacts with the enzyme to create a stable complex. The authors go on to examine the molecular details on DNA deformation with drug/specific residue contacts. By focusing on the ternary complex between topo/topotecan/DNA they have gained key insight to our understanding of the dynamics of the process.
Article Source: PloS One Website
Topotecan and Human Topoisomerase I enzyme are available from TopoGEN, Inc.