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Topotecan and its Effects on Human Topoisomerase I

Topotecan and its Effects on Human Topoisomerase I

A very nice paper has been recently published in the free access journal PLoS One.  These investigators are starting to ask important structural questions about how Topotecan, a clinically useful topoisomerase I poison, interacts with the enzyme to create a stable complex.  The authors go on to examine the molecular details on DNA deformation with drug/specific residue contacts.  By focusing on the ternary complex between topo/topotecan/DNA they have gained key insight to our understanding of the dynamics of the process.

Article Source: PloS One Website

Topotecan and Human Topoisomerase I enzyme are available from TopoGEN, Inc.

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