DNA Substrates & Markers
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DNA Substrates & Markers
Kinetoplast DNA (kDNA)
kDNA is the ideal substrate for topoisomerase II assays because it is specific for type II reaction mechanisms. Researchers can even assay for a type II enzyme in the presence of large excess of topoisomerase I.
Supercoiled pHOT-1 DNA
Supercoiled pHOT-1 DNA is a perfect substrate for assaying any topoisomerase. Specifically, the plasmid is relatively small (<3KB) which is ideal for displaying intermediate topoisomers.
Relaxed pHOT-1 DNA
Relaxed pHOT-1 DNA - ideal for assaying the supercoiling activity of DNA Gyrase.
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Complete listing of the latest Google Scholar results that reference the use of TopoGEN Products....
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Topoisomerase II Targeting and Resveratrol
In this paper the authors use a decatenation assay to identify some new topoisomerase II inhibitors from resveratrol. kDNA substrate was provided by TopoGEN. Article Source: Journal of Agricultural and Food Chemistry Topoisomerase...
In this paper the authors use a decatenation assay to identify some new topoisomerase II inhibitors from resveratrol. kDNA substrate was provided by TopoGEN. Article Source: Journal of Agricultural and Food Chemistry Topoisomerase...
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