DNA Substrates & Markers
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DNA Substrates & Markers
Kinetoplast DNA (kDNA)
kDNA is the ideal substrate for topoisomerase II assays because it is specific for type II reaction mechanisms. Researchers can even assay for a type II enzyme in the presence of large excess of topoisomerase I.
Supercoiled pHOT-1 DNA
Supercoiled pHOT-1 DNA is a perfect substrate for assaying any topoisomerase. Specifically, the plasmid is relatively small (<3KB) which is ideal for displaying intermediate topoisomers.
Relaxed pHOT-1 DNA
Relaxed pHOT-1 DNA - ideal for assaying the supercoiling activity of DNA Gyrase.
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Recently, TopoGEN was featured in the local press in order to showcase our collaboration with Nanoly Bioscience based out of Boulder. Nanoly has developed a polymer-based cage (the NanoShield) that can protect labile products fro...
Recently, TopoGEN was featured in the local press in order to showcase our collaboration with Nanoly Bioscience based out of Boulder. Nanoly has developed a polymer-based cage (the NanoShield) that can protect labile products fro...
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