Non-homologous End Joining (NHEJ) Reporter Cells

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Non-homologous End Joining (NHEJ) Reporter Cells

Human: HeLa NHEJ Reporter Cell Line with Tet-on I-Sce1

This is a HeLa cell-based reporter kit to analyze NHEJ in live cells.  Specifically this kit will identify agents (drugs, natural products, small molecules, synthetics, miRNAs, and other genes) that affect or impact NHEJ repair. The kit uses GFP as an in situ readout for NHEJ activity in a cell context.  The NHEJ process is activated with high penetrance and synchrony using Doxycycline to induce an endonuclease that specifically cuts the GFP reporter, thereby activating NHEJ. A specific reporter based assay for NHEJ can be very beneficial for anti-cancer drug discovery projects, learning more about the process of NHEJ repair and establishing intersecting pathways, druggable pathway targets, aging and disease modeling in cells.

 
Human: HeLa NHEJ Reporter Cell Line with Tet-on I-Sce1
$1,495.00

Human: HeLa NHEJ Reporter Cell Line (Includes I-Sce1 Transfection)

This is a HeLa cell-based reporter kit to analyze NHEJ in live cells.  Specifically this kit will identify agents (drugs, natural products, small molecules, synthetics, miRNAs, and other genes) that affect or impact NHEJ repair. The kit uses GFP as an in situ readout for NHEJ activity in a cell context.  The NHEJ process is activated by transfecting with an I-Sce1 expression plasmid. A specific reporter based assay for NHEJ can be very beneficial for anti-cancer drug discovery projects, learning more about the process of NHEJ repair and establishing intersecting pathways, druggable pathway targets, aging and disease modeling in cells.

 
Human: HeLa NHEJ Reporter Cell Line (Includes I-Sce1 Transfection)
$1,095.00

Human: HNSH NHEJ Reporter Cell line (Includes I-Sce1 Transfection)

This is a cell-based reporter kit designed to study NHEJ repair in a human neuroblastoma line (SH-SY-5Y) allowing the customer to screen or identify agents (drugs, natural products, small molecules, synthetics, miRNAs, and genes) that affect or impact the process of DNA repair. The kit uses GFP as an in vivo readout for the NHEJ pathway.

 
Human: HNSH NHEJ Reporter Cell line (Includes I-Sce1 Transfection)
$1,295.00

Mouse: 3T3 Fibroblast NHEJ Reporter Cell Line (Includes I-Sce1 Transfection)

DNA Repair pathways in animal cells can be divided into two main categories:  HR and NHEJ.  HR or homologous recombination is a minor pathway but very important in protecting cells from genotoxicity.  NHEJ is the major repair pathway in all animal cells and operates continuously during the entire cell cycle.  NHEJ is both error prone but also pivotal in survival of cells since it is a re-ligation pathway that maintains genome integrity.

 
Mouse: 3T3 Fibroblast NHEJ Reporter Cell Line (Includes I-Sce1 Transfection)
$1,295.00

Mouse: HNCN1.4-Sce NHEJ Reporter Cell line (Includes I-Sce1 Transfection)

This is a cell-based reporter kit designed to study NHEJ repair in a mouse neuronal cell line that can be differentiated, in vitro. This facilitates identifying agents (drugs, natural products, small molecules, synthetics, miRNAs, and genes) that affect or impact the process of DNA repair. The kit uses GFP as an in vivo readout for the NHEJ pathway.

 
Mouse: HNCN1.4-Sce NHEJ Reporter Cell line (Includes I-Sce1 Transfection)
$995.00

Custom Cell Based Screening Kit for NHEJ: Allows Customer to Create a Cell Line Host for an NHEJ Reporter

This kit will allow you to analyze NHEJ DNA repair in a specific cell lineage or cell line using a neutral GFP gene reporter.

 
Custom Cell Based Screening Kit for NHEJ: Allows Customer to Create a Cell Line Host for an NHEJ Reporter
$1,295.00
Custom Cell Based Screening Kit for NHEJ: Allows Customer to Create a Cell Line Host for an NHEJ Reporter
$895.00