TDP2 Products

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Human Tyrosyl-DNA phosphodiesterase-2, TDP-2 Assay Kit, & TDP-2 Substrate.

Human TDP-2 Assay Kit

TDP-2 is a relatively recently discovered repair protein.  Tyrosyl-DNA-phosphodiesterase 2 (unlike TDP1) is specifically directed to act on phosphotyrosyl bonds that form when topoisomerase II is covalently trapped on the DNA helix. This Kit is designed to assay Human TDP-2 activity using a novel, non-radiolabeled substrate constructed as a huTop2/DNA covalent complex (CC) intermediate.

 
Human TDP-2 Assay Kit
$345.00
Human TDP-2 Assay Kit
$445.00

Human TDP-2

TDP-2 is a relatively recently discovered repair protein. TDP2 (unlike TDP1) is specifically directed to act on phosphotyrosyl bonds that form when topoisomerase II is covalently trapped on the DNA helix. We provide high purity (>90%) Tdp2 that is catalytically active using an assay developed specifically by TopoGEN (TG1005).  We guarantee active enzyme and provide a convenient and rapid assay that does not require isotopes or binding to microtiter plates.

 
Human TDP-2
$295.00
Human TDP-2
$395.00

Tyrosyl DNA Phosphodiesterase 2 (TDP-2) Substrate

TDP-2 is specifically directed to act on phosphotyrosyl bonds that form when topoisomerase II is covalently trapped on the DNA helix. We now offer the actual DNA substrate for Tdp2.  This substrate is a native Top2/DNA covalent complex that is acted on by Tdp2 and releases free DNA.  The assay is rapidly and easily performed using a simple agarose gel electrophoretic separation.

 
Tyrosyl DNA Phosphodiesterase 2 (TDP-2) Substrate
$295.00
Tyrosyl DNA Phosphodiesterase 2 (TDP-2) Substrate
$395.00