Topo I
Topotecan Hydrochloride (Hycamtin)
Topotecan is a semi-synthetic derivative of camptothecin and anti-tumor drug that targets topo I. As a topo I poison it induces cleavage complexes.
Irinotecan (CPT-11)
Irinotecan (CPT-11) is a water soluble, semi-synthetic analogue of 20(S) camptothecin (CPT) with promising activity against a range of tumor types.
9-Nitro-20 (S) Camptothecin (Rubitecan)
Rubitecan (9-nitro-CPT) is a control poison/inhibitor of topo I with promising activity against a range of tumor types.
10-Hydroxy Camptothecin
10-Hydroxy Camptothecin is a control poison/inhibitor of topo I with promising activity against a range of tumor types.
9-Amino Camptothecin
9-Amino Camptothecin is an analog of camptothecin showing promising activity against a range of tumor types. It is provided as a control poison/inhibitor of topo I.
Camptothecin
Camptothecin is a topo I poison that both inhibits enzyme activity and stabilizes formation of topo I cleavage complexes.
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TopoGEN, Inc.
27960 County Rd. 319
Hangar B
Buena Vista, CO 81211
USA - 614-451-5810
- 614-559-3932
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Are you working on DNA-damage and repair? Would you be interested in a pre-validated cell-context system to analyze HR or NHEJ by single cell imaging or quantifying DNA repair by simple fluorescence? TopoGEN, Inc. has developed a...