Topo I
Topotecan Hydrochloride (Hycamtin)
Topotecan is a semi-synthetic derivative of camptothecin and anti-tumor drug that targets topo I. As a topo I poison it induces cleavage complexes.
Irinotecan (CPT-11)
Irinotecan (CPT-11) is a water soluble, semi-synthetic analogue of 20(S) camptothecin (CPT) with promising activity against a range of tumor types.
9-Nitro-20 (S) Camptothecin (Rubitecan)
Rubitecan (9-nitro-CPT) is a control poison/inhibitor of topo I with promising activity against a range of tumor types.
10-Hydroxy Camptothecin
10-Hydroxy Camptothecin is a control poison/inhibitor of topo I with promising activity against a range of tumor types.
9-Amino Camptothecin
9-Amino Camptothecin is an analog of camptothecin showing promising activity against a range of tumor types. It is provided as a control poison/inhibitor of topo I.
Camptothecin
Camptothecin is a topo I poison that both inhibits enzyme activity and stabilizes formation of topo I cleavage complexes.
-
TopoGEN, Inc.
27960 County Rd. 319
Hangar B
Buena Vista, CO 81211
USA - 614-451-5810
- 614-559-3932
- Mon-Fri: 8AM to 5PM
Closed Saturday and Sunday 
Useful Links
Latest News
Complete listing of the latest Google Scholar results that reference the use of TopoGEN Products....
Latest Blogs
In this paper the authors use a decatenation assay to identify some new topoisomerase II inhibitors from resveratrol. kDNA substrate was provided by TopoGEN. Article Source: Journal of Agricultural and Food Chemistry Topoisomerase...