Topo I

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Topo I Inhibitors and Poisons

Topotecan Hydrochloride (Hycamtin)

Topotecan is a semi-synthetic derivative of camptothecin and anti-tumor drug that targets topo I.  As a topo I poison it induces cleavage complexes.

 
Topotecan Hydrochloride (Hycamtin)
$85.00

Irinotecan (CPT-11)

Irinotecan (CPT-11) is a water soluble, semi-synthetic analogue of 20(S) camptothecin (CPT) with promising activity against a range of tumor types.

 
Irinotecan (CPT-11)
$85.00

9-Nitro-20 (S) Camptothecin (Rubitecan)

Rubitecan (9-nitro-CPT) is a control poison/inhibitor of topo I with promising activity against a range of tumor types.

 
9-Nitro-20 (S) Camptothecin (Rubitecan)
$85.00

10-Hydroxy Camptothecin

10-Hydroxy Camptothecin is a control poison/inhibitor of topo I with promising activity against a range of tumor types.

 
10-Hydroxy Camptothecin
$85.00

9-Amino Camptothecin

9-Amino Camptothecin is an analog of camptothecin showing promising activity against a range of tumor types.  It is provided as a control poison/inhibitor of topo I.

 
9-Amino Camptothecin
$85.00

Camptothecin

Camptothecin is a topo I poison that both inhibits enzyme activity and stabilizes formation of topo I cleavage complexes.

 
Camptothecin
$85.00