Topoisomerase Related Drugs
Topotecan Hydrochloride (Hycamtin)
Topotecan is a semi-synthetic derivative of camptothecin and anti-tumor drug that targets topo I. As a topo I poison it induces cleavage complexes.
Irinotecan (CPT-11)
Irinotecan (CPT-11) is a water soluble, semi-synthetic analogue of 20(S) camptothecin (CPT) with promising activity against a range of tumor types.
9-Nitro-20 (S) Camptothecin (Rubitecan)
Rubitecan (9-nitro-CPT) is a control poison/inhibitor of topo I with promising activity against a range of tumor types.
10-Hydroxy Camptothecin
10-Hydroxy Camptothecin is a control poison/inhibitor of topo I with promising activity against a range of tumor types.
9-Amino Camptothecin
9-Amino Camptothecin is an analog of camptothecin showing promising activity against a range of tumor types. It is provided as a control poison/inhibitor of topo I.
Camptothecin
Camptothecin is a topo I poison that both inhibits enzyme activity and stabilizes formation of topo I cleavage complexes.
Etoposide (VP16)
Etoposide (VP16) is a control poison/inhibitor of topo II. It is also included in the topo II drug screening kit.
Ciprofloxacin
Ciproflaxin is a control poison/inhibitor of DNA Gyrase and Topo IV. This is also included in the Topo IV Drug Screening Kit.
Genistein
Genistein is an isoflavone and inhibitor of tyrosine protein kinases reported to induce topo II dependent cleavages.
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Topoisomerase levels determine chemotherapy response in vitro and in vivo Darren J. Burgess*, Jason Doles†, Lars Zender*, Wen Xue*, Beicong Ma*‡, W. Richard McCombie*, Gregory J. Hannon*‡, Scott W. Lowe*‡§, and Michael T. Hemann*†...