Topoisomerase Related Drugs
Topotecan Hydrochloride (Hycamtin)
Topotecan is a semi-synthetic derivative of camptothecin and anti-tumor drug that targets topo I. As a topo I poison it induces cleavage complexes.
Irinotecan (CPT-11)
Irinotecan (CPT-11) is a water soluble, semi-synthetic analogue of 20(S) camptothecin (CPT) with promising activity against a range of tumor types.
9-Nitro-20 (S) Camptothecin (Rubitecan)
Rubitecan (9-nitro-CPT) is a control poison/inhibitor of topo I with promising activity against a range of tumor types.
10-Hydroxy Camptothecin
10-Hydroxy Camptothecin is a control poison/inhibitor of topo I with promising activity against a range of tumor types.
9-Amino Camptothecin
9-Amino Camptothecin is an analog of camptothecin showing promising activity against a range of tumor types. It is provided as a control poison/inhibitor of topo I.
Camptothecin
Camptothecin is a topo I poison that both inhibits enzyme activity and stabilizes formation of topo I cleavage complexes.
Etoposide (VP16)
Etoposide (VP16) is a control poison/inhibitor of topo II. It is also included in the topo II drug screening kit.
Ciprofloxacin
Ciproflaxin is a control poison/inhibitor of DNA Gyrase and Topo IV. This is also included in the Topo IV Drug Screening Kit.
Genistein
Genistein is an isoflavone and inhibitor of tyrosine protein kinases reported to induce topo II dependent cleavages.
HU-331
HU-331 is a cannabinoid-based quinone with potential anticancer activity. It has anti-topo IIa activity as a catalytic inhibitor rather than a poison.
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A new method to quantify endogenous Topoisomerase action in E. coli cells is nicely described in this paper. The technique is based on the In Vivo Link Kit, also known as the ICE bioassay. Article Source: American Society for Mi...